1,3,5-Trisubstituted-1H-Pyrazole Derivatives as New Antimicrobial Agents: Synthesis, Characterization and Docking Study

Ismail AH, Abdula AM, Taha MM

Abstract

A four new 1,3,5-trisubstituted pyrazole derivatives (2a-d) were synthesized from the reaction of corresponding 1,3-diaryl-2-propene-1-one compounds (1a-d) with phenyl hydrazine in glacial acetic acid. The new pyrazole derivatives were screened for their antimicrobial activities against several bacterial species and candida albicans. Autodock approach was used to examination the interaction modes of substituted pyrazoles within the active pocket of GlcN-6-P enzyme.