2D-QSAR Studies of Substituted Pyrazolone Derivatives as Anti-Inflammatory Agents

Research Article

Rishikesh V. Antre, Rajesh

Abstract

A QSAR study was performed on a series of substituted pyrazolone derivatives. The compounds in the selected series were characterized by spatial, molecular and electrotopological descriptors using QSAR module of molecular design suite (V-Life MDS 4.0). In present research paper we reported 2D-QSAR studies of substituted pyrazolone derivatives. Correlations between inhibitory activities and calculated predictor variables were established through partial least square regression (stepwise forward) method.f

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