A green solvent-free protocol for the synthesis of poly-substituted quinolines using 3-methyl-1-sulfonic acid imidazolium chloride {[Msim]Cl} as an efficient and homogeneous catalyst

Abdolkarim Zare, Maria Merajod

Abstract

An efficient, simple and clean protocol for the synthesis of poly-substituted quinolines from2-aminoaryl ketones and carbonyl compounds possessing a reactivemethylene group in the presence of catalytic amount of Brønsted acidic ionic liquid 3-methyl-1-sulfonic acid imidazoliumchloride {[Msim]Cl} is described (Friedländer protocol). Using this protocol, the products are produced in high yields and short reaction times.