A New Paradigm for Developing Antiviral Drugs Exemplified by the Development of Supremely High Anti-HIV Active EFdA

Hiroshi Ohrui

Abstract

The fundamental concept for developing anti-viral modified nucleoside was proposed. An idea to use 4’-C-substituted-2’-deoxynucleoside derivatives based on the fundamental concept was also proposed to solve the problems of the existing highly active antiretroviral therapy (HAART).