Sandeep V.Shinde, Wamanrao N.J
Abstract
An efficient synthesis of 2-substituted oxazolines from aldehydes and 2-amino alcohol using the combination of NaBrO3 with NaHSO3 is reported. The in situ generated HOBr acts as dehydrogenating agent to convert the initially formed oxazolidine from aldehyde and 2-amino alcohol to furnish 2-substituted oxazolines. This one-pot synthesis is characterized by mild reaction condition, broad scope, high yields, and its preparative simplicity.