A Novel Synthesis of Substituted Pyrimidino-3-Substituted Thiocarbamides

D. T. Tayade, D. A. Pund, R. A

Abstract

Pyrimidines, thiocarbamides and various analogue of pyrimidino containing nucleus have their own importance in medicinal, pharmaceutical, agricultural and biochemical sciences. So, it was thought interesting to synthesize 2-amino-4-hydroxy-6-methylpyrimidine by interacting guanidine with acetoacetic ester and its reaction with various isothiocyanates in acetone-ethanol medium. 1-(4-Hydroxy-6- methylpyrimidino)-3-substitutedthiocarbamide was isolated as final product with greater yield and purity.