Research Article
Devyani J Desai, Shailee Sh
Abstract
Introduction: The hemodynamic response to endotracheal intubation, pneumoperitoneum and extubation canincrease perioperative morbidity and mortality. Dexmedetomidine is a highly selective alpha 2 adrenoreceptoragonist, routinely used to attenuate hemodynamic stress response. Magnesium Sulphate also inhibitscatecholamine release from adrenal glands. It can modulate the neurohumoral responses observed duringlaparoscopic surgeries.Aim and objectives: To compare the effectiveness of intravenous Dexmedetomidine and Magnesium Sulphateas an adjunct during anesthesia for laparoscopic cholecystectomy.Materials and method: After taking permission from institutional ethical committee, patients of 18-60 years ofeither sex and American society of anesthesia grade I and II were divided into two groups of 35 each. In Group D,Dexmedetomidine 1 μg/kg and Group M, Magnesium Sulphate 40 mg/kg over 15 min in 20 ml NS were givenintravenously before induction of general anesthesia. Peri operative hemodynamic parameters were noted as wellas postoperative analgesia and sedation were assessed.Results: There was fall in mean arterial pressure and heart rate after giving Magnesium Sulphate andDexmedetomidine infusion, which further decreased after giving propofol in both the groups. There was rise in boththe parameters after intubation and pneumoperitoneum but remained lower than the baseline throughout theintraoperative period in both the groups. The fall in mean arterial pressure and heart rate was more in MagnesiumSulphate group than in Dexmedetomidine group (p<0.001). Postoperative analgesia and sedation were comparablein both the groups.Conclusion: Both, Dexmedetomidine 1 μg/kg and Magnesium Sulphate 40 mg/kg were able to attenuatehemodynamic response to anesthesia and surgical manipulation during laparoscopic cholecystectomy. However,Magnesium Sulphate produced better hemodynamic stability compared to Dexmedetomidine.