A simple and efficient method for three-component coupling of aldehyde, amine and alkyne via C-H activation

P.Narsimha, A.Venkat Narsaiah

Abstract

An efficient three-component condensation has been carried out to afford the propargylamines.All the reactionswere promoted by a catalyst copper acetylacetonate at toluene reflux and completedwithin 2.5 to 4.5 hours. Thismethod has proved to be applicable towide range of substrates such as aromatic and aliphatic systems.

Relevant Publications in ChemXpress