Aclean one-pot synthesis of pyrano[2,3-d]pyrimidine derivatives catalyzed by hexadecyltrimethyl ammonium bromide in aqueous media

Na Gao, Sheng-Hui Li, Ji-Tai L

Abstract

An efficient and convenient approach to the synthesis of pyrano[2,3- d]pyrimidine derivatives using hexadecyltrimethyl ammonium bromide (HTMAB) as catalyst in aqueousmedia is described. Thismethod provides several advantages such as neutral conditions, high yields and simple workup procedure, In addition, water was chosen as a green solvent.

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