Actinomycete from coal fields of Andhra Pradesh and their antibiotic production

B.V. Gopinath, Krishna Bolla,

Abstract

Diversified actinomycete species were isolated from coal fields of Andhra Pradesh and dominant genera were separated. A total of eleven antibiotic microbial producers have been isolated from the coal soil, five of them have shown activity against both Gram-positive and Gram-negative bacteria. On the other hand, six isolates were only active against Gram-positive bacteria. They exhibited resistance to ampicillin, tetracycline, rifampicin, methicillin, streptomycin, streptothricin and chlorotetracycline and taken HIV-drugs like Lamostad-N-30, Trimune-30, zidovudine contain L = Laminarin, S = Stavudine and n = nevirapine but slight resistance factor identified by HIV-drugs against mandamarri strain of coal site of Andhra Pradesh. Metabolites produced by the strain showed good antimicrobial activity against Gram-positive and Gramnegative bacteria.