G.Madhusudhan, Raman Vysabhatt
Abstract
A facile and efficient synthesis of 2-bromo-5-methyl pyrazine is described. The synthetic scheme involves the conversion of 5-methylpyrazine-2-carboxylic acid to the corresponding amide which on Hofmann degradation gives the amine compound. This amine compound on diazotization followed by in-situ bromination produces the targeted 2-bromo-5-methyl pyrazine.