An efficient synthesis and quantitative structure-activity relationship studies on some substituted 1,2-diazaphenanthrenes as potential antimicrobial agents

Manisha Sharma

Abstract

A new series of 1,2-diazaphenanthrene derivatives 3a-p has been synthesized and subjected to evaluate their antibacterial properties. All the synthesized compounds of the series elicit remarkable activity in comparison to standard drug (ampicillin). A number of descriptors were tested to adjudge a quantitative correlation between activity and structural features. However, significant correlation has emerged between activity and physicochemical parameters viz. hydrophobic parameter (log P). Moreover, results are interpreted on the basis of multiple regression analysis and cross-validation methodology.