Analytical applications of atomic emission spectrometry for the microdetermination of sildenafil, tadalafil and vardenafil drugs employed in the erectile dysfunction therapy.

Sabry Kh.Mohamed, Saad S.Al Za

Abstract

Ion – associate complexes of sildenafil, tadalafil and vardenafil hydrochlorides with potassium ferricyanide and ammonium reineckate were precipitated and the excess unreactedmetal complexwas determined.Anewmethod using atomic emission spectrometry for the determination of the above drugs in pure solutions, in pharmaceutical preparations and urine of diabetic patients type 2 was given. The drugs can be determined by the affort method in the ranges 0.47 - 123.24, 0.53 - 139.23 and 0.52 – 136.37 ìgmL-1 solutions of Sd, Td and Vd, respectively.