Analytical method development and validation protocol for Lornoxicam in tablet dosage form

Atul R. Bendale, Jigneshkumar

Abstract

Lornoxicam (chlortenoxicam) is a non steroidal anti- inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and parental dosage formulation. Lornoxicam is a yellow or slightly yellow powder. It is slightly soluble in water, soluble in sodium hydroxide, slightly soluble in methanol. A simple spectrophotometric method was developed for the determination of lornoxicam in pharmaceutical tablet dosage form. Lornoxicam exhibiting λ max at 258 nm in mobile phase (0.05 M NaOH) and obeyed linearity in the concentration range of 5-30mcg. The proposed method was statistically validated.

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