Analytical utilities of atomic absorption and atomic emission spectrometry for the microdetermination of sildenafil, tadalafil and vardenafil drugs employed in the erectile dysfunction therapy

Sabry K.Mohamed, Rania Gaber

Abstract

Ion – associate complexes of sildenafil;(Sd), tadalafil;(Td) and vardenafil;(Vd) hydrochlorides with iodomercurate(II),[HgI4]-2 and iodo-bismuthate(III), [BiI4]-1 were precipitated and the excess unreacted mercury or bismuth complex was determined.Anewmethod using atomic emission and atomic absorption spectrometry for the determination of the above drugs in pure solutions and in pharmaceutical preparations is given. The drugs can be determined by the affortmethod in the ranges 0.948 - 56.88, 0.998 - 59.88 and 0.976 – 58.56 ìg.mL-1 solutions of Sd, Td andVd, respectively.