Original Article
Nikhila Vengala
Abstract
Background: Flax seeds have been shown to have multiple benefits in cardiovascular disorders. Objective: To evaluate Antihyperlipidemic activity of methanolic fraction of flax lignan concentrate (MF-FLC) obtained from Linum usitatissium L., Linaceae in nicotinamide-STZ induced diabetic hyperlipidemia rats. Methods: Male Wistar rats were used for the study. The IAEC of Poona college of Pharmacy approved the proposal. Protocol no. CPCSEA/01/14. Diabetes was induced in rats by nicotinamide-STZ. Diabetic animals were divided into five groups: Diabetic atherosclerosis control, Atorvastatin (10 mg/kg), MF-FLC (200 mg/kg), MF-FLC (400 mg/kg), and MF-FLC (800 mg/kg). After the confirmation of diabetes, rats were treated with cholesterol (4% w/w) and cholic acid (1% w/w) for 45 days. After 15 days of cholesterol treatment, atorvastatin and MF-FLC treatment was given to respective groups for 30 days. Non-diabetic atherosclerosis group received cholesterol-cholic acid treatment alone. The control group was given coconut oil as vehicle. Results: Treatment of MF-FLC (400 mg/kg) and atorvastatin (10 mg/kg) significantly reduced systolic blood pressure (p