Anti-tumor activity of N4[(E)-1-(2-hydroxyphenyl)methylidene]iso-nicotinohydrazide and Its Ti (IV) and Cu (II) complexes on K562 and Jurkat

Fahmideh Shabani, Shahriar Gha

Abstract

N4[(E)-1-(2-hydroxyphenyl)methylidene] isonicotinohydrazide abbreviated as NHPM were synthesized and characterized. Ti(IV) and Cu(II) metal complexes of this ligand prepared by reaction of fluoride salt of Ti(IV) and acetate salt of Cu(II) with NHPM in dry acetonitrle. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR and UV–Visible spectroscopy. These new complexes showed excellent antitumor activity against two kind of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.