Aromatic Heterobicyclics-Based Design of Aldose Reductase Inhibitors as Drug Candidates for the Treatment of Diabetic Complications

Zhongfei Han, Nino Rcheulis

Abstract

Aldose reductase (ALR2) plays a pivotal role in the development of diabetic complications. ALR2 inhibitors (ARIs) have proven efficient to prevent and delay the chronic diseases, and thus attracted significant research interest. This article reviews a series of aromatic heterobicyclics-based ARIs developed over recent years, and discusses about their structure-activity relationships as well as their multifunctionalities such as antioxidant property