Association of allellic polymorphism of tumor necrosis factor - alpha (rs1800629) factor with the development of immune microtrombovasculitis and immune trombicytopenia in adults

D.S. Matkarimova, H.Y. Karimov

Abstract

Immune microtrombovasculitis (IMTV, ShenleinHenoch purpura) and immune thrombocytopenia (ITP) are immune complex diseases with unclear etiology [2,5]. Studies aimed at studying the etiological and pathogenetic mechanisms of development of IMTV and ITP proved that diseases are associated with a variety of factors, which allows them to be defined as multifactorial [1, 3]. The molecular basis underlying the development of IMTV and ITP is not fully understood; however, some facts confirm the opinion that genes play a crucial role in the pathogenesis of these diseases [6,11,17,19].