Bilateral Internuclear Ophthalmoplegia, Deficiency and High Dose Administration of Vitamin D in Pediatric-Age Multiple Sclerosis: A Pediatric Case Report and Review of the Literature

Genç Sel C, AltĂƒâ€žĂ‚Â±aylÃ

Abstract

Oculomotor Disorders (OMDs) can be seen as the initial symptoms or during the course of multiple sclerosis (MS). Bilateral internuclear ophthalmoplegia (BINO) is a rare observation as clinical MS onset. BINO and its prognostic value in pediatric-age MS patients are not absolutely known. Vitamin D deficiency is thought to be associated with an increased disease activity in MS and vitamin D is supposed to be a potent immunomodulatory agent. Vitamin D deficiency, its probable effects on the disease pathogenesis, and high dose administration to a pediatric age patient presented with BINO are discussed in this report.