Biocatalytic reduction of aromatic ketones with the aid of electrochemical regeneration of the coenzyme

Tomoko Matsumura, Takamitsu Ut

Abstract

Halogenated aromatic ketones were reduced electrochemically using dried cell of Geotrichum candidum as a catalyst with high enantioselectivity. Enzymes in the dried cell catalyzed both reactions to reduce substrates and to recycle the coenzyme using electric power, so any additional enzyme or co-substrate for coenzyme recycling was not necessary.