Biotechnology | Aquaculture | Biochemistry 2020: Zinc deficiency, and hypovitaminosis D, connection with autism spectrum disorders - L.Hetemi - Institute of Biochemistry UBT university



Biotechnology | Aquaculture | Biochemistry 2020: Zinc deficiency, and hypovitaminosis D, connection with autism spectrum disorders - L.Hetemi - Institute of Biochemistry UBT university ­­ L.Hetemi Institute of Biochemistry UBT University             Extended Abstract Introduction: Inspiration is from my family: (the child of my sister). From the outcome of the research on: Autism and food intolerance we found that the connection of Autism and food intolerance is very strong, while causes of food intolerance besides the deficiency of digestive enzymes, a special role in this development also have zinc deficiency.   Mechanism: Zinc with tens and dozens of functions in the body, has an important role in pancreas, where digestive enzymes are produced, also cause deficiencies in aminoacids, which are an integral part of the proteins. The aminoacids also function as chemical blocks on neurotransmitters with key role in the brain to affect the emotional state and behavior. For its reason the proper balance of these nutrients are essential for a healthy development: emotional and cognitive in children, also the role of proteins in protein synthesis (exactly another cause for food intolerance mechanism is the lack of those in protein buildings). Furthermore, tryptophan deficiency as the aminoacid-serotonin synthesizing again an interconnection with food either as a deficit or as an etiology, but, also serotonin links in the evaluation of ASD and neuromental disordres. Zinc with his antibodies also has a role in the pancreas as transporter and nerve structure, so it has an important role as neurotransmitter through: GABA-anxiety. This did in deeper research considering that zinc begins with his functions from the cellular level. Zinc deficiency in pregnancy: Zinc is widely recognized for critical roles in the cell division, differentiation and function that are essential for tissue growth, so zinc homeostasis in the brain is affected the lack of zinc in the diet and its alteration can cause brain dysfunctions. It may be also one of the reasons, whether in enzymatic deficits also giving psycho-motor disorders since: oligominerals are very important in developing the CNS.   Method and materials: Over 65 patients, aged 5-11 years, have been tested for serum zinc levels (the research continues with patients testing, and for vitamin D level), at the biochemistry laboratory, patients are confirmed with ASD diagnosis, and from clinical aspect are followed from neurologist specialist, also worth noting that these patients around 90% of them are also tested for food intolerance, and are 99% intolerant in some foods. Zinc levels have been tested in serum, 2.5 ml blood, serum intake: 1.5ml serum, working method: photometric method as analytical methods. Requires: 0.8 mL (minimum: 0.2 mL) serum . Blood zinc level reported in μmol/L. Useful in detecting zinc deficiency. : Zinc is an essential element; it is a critical co-factor for carbonic anhydrase, alkaline phosphatase, RNA and DNA polymerases, alcohol dehydrogenase, and many other physiologically important proteins. The peptidases, kinases, and phosphorylases are most sensitive to zinc depletion. Zinc is a key element required for active wound healing. Zinc deficiency findings and the connection to autism are very important for ongoing follow-up since treatment with zinc supplements has given positive signs to our investigated autistic patients, and this is an reason that this deficit is probably transmitted by a pregnant mother, will be broadly explained in the research, that all of these factors also affect the responsible genes. Zinc is used by your body in cell production and immune functions. There is still a lot more to learn about zinc, but we do know that zinc is an essential part of growth, sexual development, and reproduction. Risk factors: If you’re pregnant and have zinc deficiency, your baby might not have what it needs to develop properly in your womb. And if you and your partner are trying to become pregnant, zinc deficiency could make it difficult. That’s because zinc deficiency may lead to impotence in men. Diagnosing zinc deficiency: Zinc is distributed in trace amounts among the cells in your body, making it difficult to detect zinc deficiency through a simple blood test. If your doctor suspects a zinc deficiency, they will need to test your blood plasma for an accurate reading. Other tests for zinc deficiency include a urine test and an analysis of a strand of your hair to measure the zinc content. Sometimes zinc deficiency is a symptom of another condition. For example, some conditions may cause zinc to be processed in your body but not absorbed well. Zinc deficiency can also lead to copper deficiency. Your doctor will be aware of these possibilities. They may do additional testing to get to the root of your deficiency. Zinc is a nutrient that plays many vital roles in your body. Because your body doesn’t naturally produce zinc, you must acquire it through food or supplements.This article explains everything you need to know about zinc, including its functions, health benefits, dosage recommendations and potential side effects. Tips for preventing zinc deficiency: There are ways a person can prepare and eat foods to make zinc more available in their daily diets.For example, a person can soak beans in water before cooking them. This reduces the presence of phytates, making it easier for the body to process the zinc.Choosing leavened grain products can also help reduce the number of phytates, increasing the amount of zinc for the body to use. This work is partly presented at EuroSciCon Joint Event On Biotechnology , Biochemistry and Aquaculture August 08-09, 2019 | Paris, France How to cite this article: L.Hetemi. "Editorial Highlights for International Research Journal of Biochemistry and Bioinformatics".doi: 10.37421/irjbb.2020.10.001  

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