Case Report
Panpan Zhang, Jie Li, Xu Zh
Abstract
Primary neuroendocrine carcinoma of gallbladder (GB-NEC) is extremely rare and the clinical presentations of most patients are nonspecific. Pathological examination and immunohistochemical staining are required for the diagnosis of GB-NEC. It has a poor prognosis and often escapes detection until advanced stage. Because of rarity of GB-NEC, there is limited evidence about its clinic pathologic characteristics, treatment and prognosis. Here we reported three cases of incidental metastatic GB-NEC. Multidisciplinary treatments were adopted and they present good response and had long survival. We aimed to provide a comprehensive literature review on GB-NEC and compare it with carcinoma of gallbladder and neuroendocrine neoplasms of other origins.