Coexistence of Familial Amyotrophic Lateral Sclerosis and Sporadic Inclusion Body Myositis – A Case Report

Udaya Bhat, Bo Wang, Padma

Abstract

Many inclusion body myositis (IBM) patients have been misdiagnosed as amyotrophic lateral sclerosis (ALS). We report a case of IBM coexisting with familial ALS. Clinically, Inclusion body myositis (IBM) patients have been misdiagnosed as amyotrophic lateral sclerosis (ALS). Recent studies have shown that mutations of valosin-containing protein (VCP) are involved in ALS and IBM. ALS and IBM may share similar pathogenesis of multisystem proteinopathy. We report a case of sporadic IBM coexisting with familial ALS (fALS).