Comparison of L-Arginine and Hydroxyurea Interactractions with Transitional Metal Ions.

Sangeeta Parab, AV Chitre,


No* is a free radical with one free electron and as such it is very highly reactive and particularly it interacts with transitional metals. Nitric oxide, gas is an important signaling molecule in the body of mammals, including humans and is an extremely important intermediate in chemical industry In biological systems there are many enzymes, which contain transitional elements like iron, copper and manganese, which are the most probable sites for nitric oxide to react. Such type of interactions results in considerable modification of the enzyme functions resulting pathological and even genetic disorders. This needs a critical amount of nitric oxide in the system for proper functioning. To observe the effects of NO*, various NO* donor compounds are used. Hydroxyurea (HU) is shown to increase the levels of NO*.L-arginine is one of the non- essential amino acids. In the body L-arginine is used to make nitric oxide, which reduces blood vessel stiffness, increases blood flow and improves blood vessel function. The visible spectra of some transitional metals Cu, Fe(II),Fe(III),Cr, Mn, Ni have been studied individually in presence of hydroxyurea (HU) with varying amounts .The spectra are also studied for the effect of varying amounts of metal ion on hydroxyurea. To observe how arginine itself acts on transitional metal ions. Even effect of Hydroxyurea on metal-arginine binding is also studied. The evaluation of these spectra is carried out for its binding parameters with the help of scatchard plots. The work has revealed certain very significant and interesting data which can have a lot of bearing on many chemical, biological and environmental aspects.

Relevant Publications in Research & Reviews: Journal of Chemistry