Conventional and Microwave Assisted Synthesis of Chalcones and their Biological Evaluation

Mohammed Rayees Ahmad, V. Giri

Abstract

Chalcones are synthesized by Claisen-Schmidt condensation, which involves cross-aldol condensation of appropriate aldehydes and ketones by base catalyzed or acid catalyzed reaction followed by dehydration. Chalcone is a common natural pigment and one of the important intermediate in the biosynthesis of flavonoids. Chalcones are synthesized by conventional and microwave assisted synthesis methods. By microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. The compounds have been screened for antibacterial activity and antioxidant activity.