Design, Synthesis and Pharmacological Evaluation of New Series of 2-Pyrazoline Containing s-Triazine and their Derivatives

Ramkumar P Dongre and Shantila

Abstract

In the present investigation, a series of some novel 4,6-diethoxy-N-(4-(4,5-dihydro-5-phenyl-1H-pyrazol-3-yl) Substituted phenyl)-1,3,5-triazin-2-amine 7(a-h) have been synthesized by the treatment of 1-(4-(4,6-diethoxy-1,3,5- triazin-2-ylamino)phenyl)-3-substituted phenyl prop-2-en-1-one (CHAlcone) (6a-6h) with hydrazine hydrate in DMF. The structure of newly synthesized compounds was confirmed by the IR, 1H NMR and Mass spectral analysis. All the synthesized compounds were evaluated for anti-fungal and anti-bacterial activity. Most of the compound showed potent activity.