Research Article
Maraia F. Elmhdwi
Abstract
Reactive oxygen species and free radicals are involved in the nephrotoxicity induced by the synthetic anticancer drug cisplatin. The nephrotoxicity effects of carob pods and leaves (100 and 200 m/kg, p.o.) were investigated using cisplatin (10mg/kg body weight, i.p.) to induce oxidative renal damage in mice. The results showed that cisplatin administration caused abnormal renal functions in all studied mice. Serum urea and creatinine concentration were significantly higher (p