Enhanced oxidation of salbutamol sulphate at acetylene black-dihexadecyl hydrogen phosphate composite film electrode and its analytical applications

Xiaofeng Yang, Fang Wang, Shen

Abstract

An electroanalytical method for determination of salbutamol sulphate was established on basis of enhanced oxidation of salbutamol sulphate at an acetylene black-dihexadecyl hydrogen phosphate composite film modified glassy carbon electrode (AB-DHP/GCE).Under optimalworking conditions, this oxidation current was proportional to salbutamol sulphate concentration range from4.0ï‚´10-7 to 7.5ï‚´10-6mol L-1 and from7.5ï‚´10-6 to 1.0ï‚´10-4mol L-1with a low detection limit of 1.0ï‚´10-7 mol L-1 for 2 min accumulation at open circuit (S/N = 3). The proposed method was applied to the determination of salbutamol sulphate in tablets and the results were satisfying.