Evaluation of anti-inflammatory potential of Ricinus communis Linn leaves extracts and its flavonoids content in Wistar rats

Anil Kumar Saini1, Rohit Goyal

Abstract

The present study was aimed to screen Ricinus communis (RC) leaves for anti-inflammatory potential using carrageenan-induced paw edema (Acute model) and cotton pellet induced granuloma models (Sub-chronic model) in Wistar rats. For this 80% methanolic extract (ME) at two dose levels of 250 and 500 mg/kg and total flavonoids fractions (FF) at three different doses 25, 50 and 100 mg/kg, were studied in acute model. The ME (500 mg/kg) and FF 50 mg/kg showed potent anti-inflammatory action in this model, Moreover FF (50 mg/kg) had shown almost same effect as shown by FF at the dose of 100 mg/kg. Hence, ME (500 mg/kg) and FF (50 mg/kg) have been selected for further evaluation in sub-chronic model. The results of ME (500 mg/kg) and FF (50 mg/kg) were at par with diclofenac sodium (20 mg/kg). The study shows the RC leaves have anti-inflammatory potentials and flavonoids are dominating this activity in the extract.