Fluorometric Investigation on the Interaction of 5-Bromo and 5- Iodouracil with Bovine Serum Albumin

S. Bakkialakshmi and D. Chandr

Abstract

The Interaction of 5-Bromouracil (5BU) and 5-Iodouracil (5IU) with bovine serum albumin (BSA) were studied by spectroscopic method. Quenching of fluorescence of serum albumin by these drugs was found to be a static quenching process. Based on the interaction studies carried out the number of binding sites for drug on protein have been evaluated. The binding constant (Ka) were 2.013 x 104 and 4.062 x 104 L mol-1 for 5BU and 5IU.  

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