Research Article
Azadeh Montaseri, Leila Roshan
Abstract
Articular cartilage is a specialized type of connective tissue which is populated exclusively with chondrocytes [1, 2]. The injured cartilage has a restricted capacity for self repair due to lack of vascularity and scarce number of cells [3], if the damaged cartilage is left untreated, over a period of time progresses to arthritis associated with pain, joint dysfunction and ultimately disability [4, 5]. The results indicates that in comparison to untreated and microdrilling methods in recovery of damaged cartilage, chondrocytes seeded onto PCL scaffolds and pretreated with PDGF has stimulatory effect on formation of hyaline cartilage-like tissue in in vivo condition. Future investigations are needed to evaluate PDGF precise effects on cartilage matrix components after in vivo transplantation.