Graft versus Leukemia Could Participate of Efficacy of Blinatumomab in Patients with B-Lineage Acute Lymphoid Leukemia Relapsing after Stem Cell Transplantation

Anne-Marie Ronchetti, Chris

Abstract

We report here the first clinical case of GvL post Blinatumomab treatment in acute lymphoblastic leukemia relapsing after allo stem cell transplantation. This effects accompanied a skin GvHD and has been documented by skin biopsy, immune-staining and FISH. We thus hypothesize that the GvHD may have contributed to disease eradication in this patient, the allogeneic setting reinforcing the immunological efficacy of blinatumomab through a GvL effect. Blinatumomab could actually represent a very interesting therapeutic approach in relapse and/or in prevention of relapse after alloSCT.