Green chemistry approach for synthesis of 5-arylidine barbituric acid derivatives by hydrotrope induced Knovenagel condensation in aqueous medium

Santosh Kamble, Gajanan Rashin

Abstract

An efficient Knovenagel condensation of babituric acid with different aromatic aldehyde in aqueous hydrotropic solution affording the corresponding 5-arylidine barbituric acid derivatives in very short time of reaction with high yield and purity.