Research Article
Yoav Leiser, Yasmine Ghantous,
Abstract
Aim: Our aim was to investigate the incidence of HPV related oral squamous cell carcinoma in the Israeli population. Materials and methods: HPV typing was done by immunostaining for P16 of Tissue-Array sections, and PCR amplification from paraffin-embedded tissues [PCR Taq Mix (Promega Corporation, Israel)], on oral squamous cell carcinoma tissues spanning the period from 1996 to 2014. Results: Immunoreactivity for P16 protein was found in 32 cases (39%), HPV16 DNA typing was found in 23 cases (28%), the HPV positive patients were significantly younger than HPV negative group, and demonstrated a higher histological differentiation. Conclusion: A positive correlation between HPV infection and OSCC was found in the presented study; these results imply a possible involvement of HPV infection in oral carcinogenesis.