Value Added Abstract
There is considerable debate on how diabetes mediates recovery after stroke. Studies to unravel the underlying mechanisms are critical in efforts to develop therapies to improve poor post-stroke recovery profiles in diabetes induced obesity population. A recent preclinical study showed that the stroke-induced neurogenesis and neuroplasticity is severely impaired due to obesity-induced type 2 diabetes. However, factors such as interactions between microvascular changes, oxidative stress and insulin resistance (IR); and their role in poor recovery profiles in diabetes population warrant further consideration. Understanding of these mechanisms is important in developing cardiovascular risk-management pathways in this subgroup of population who are at increased risk of poor clinical outcomes following acute stroke.