In vitro antibacterial, antifungal and cytotoxic activity of three Bangladeshi Bridelia species

Adeeba Anjum, Mohammad R. Haqu

Abstract

The organic soluble extractives of three Bridelia species, B. verrucosa, B. stipularis and B. tomentosa growing in Bangladesh were subjected to screening for antibacterial, antifungal and cytotoxic activities. All extractives showed moderate to strong antimicrobial activity against 13 Gram positive and Gram negative bacterial strains and three fungi where the stem bark of B. tomentosa demonstrated highest inhibition of growth with zone of inhibition of 23.2 mm againstBacillus cereus and 17.5 mm against Candida albicans. The crude extractives of all three plants of Bridelia species exhibited cytotoxic activity against brine shrimp nauplii having significant LC50 and LC90.