Original Articles
Thitiporn Charueksereesakul1,
Abstract
Psoriasis, known as the incurable disease, is a chronic inflammatory disease characterize by hyperproliferative keratinocytes. The causes of this disease are unclear, and many side effects are evident as a result of certain treatments of psoriasis. In this work, we aimed at studying the in vitro effect of each of these following Thai herbal extracts, Alpinia galanga L. (rhizome), Curcuma longa L. (rhizome) and Annona squamosa L.(leaf), containing anti-psoriatic activity on the expression of caspase 9, the protein known to play a critical role in the intrinsic apoptotic pathway. The HaCaT keratinocyte cell line was chosen as an in vitro model. Based on Western blot analysis, the extract derived from Annona squamosa L. leaf at all three concentrations tested significantly reduced the expression of procaspase 9 (P