Commentary
Pallavi Khanna
Abstract
Recurrent pregnancy loss or RPL is defined as a failure of two or more clinical pregnancies [1]. The incidence of RPL is estimated to be <5% with about 1 % of reproductive aged women facing three or more consecutive miscarriages. The major etiopathogenesis of RPL is idiopathic in almost 50% of cases while others include anatomic, genetic, autoimmune, endocrine and infections. When the evaluation of the patient in the above known factors is completed, the lesser known factors such as inflammation and coagulation are considered [2]. In many developing countries, anecdotal treatment of idiopathic causes are instituted without any actual evidence of inflammation. Hence, this commentary is focussed towards the role of mediators of inflammation in patients with recurrent miscarriages.