Research Article
Isolde Riede
Abstract
The central biochemical events in tumor induction are not completely understood. In a novel cell biochemical approach some questions are answered here. A proliferative mutation allows replication shortcuts to the S-phase in the cell cycle. The repair system is involved in tumor formation, and many tumor cells cannot be brought to apoptosis induction. This study illuminates the biochemical pathways of these features. Mutational translocations within the gene ALL-1 might cause human acute leukemia. In those leukemic cell lines, replication starts immediately after mitosis. Mutations thus, allow replication without control, defining ALL-1 as the proliferative gene. Cells metabolize their DNA continuously. The repair system is constantly active. Cells are blind to DNA damage by methylating agents and then replicate and repair their DNA. Induction of apoptosis fails. Thus, chemotherapy resistance is intrinsic. Tumor induction occurs by a mutation that allows replication and turns on the repair system.