Pinakin Khambhala, Shailja
Abstract
Pathogenic bacteria develop antibiotic-resistance at a pace much faster than the pace at which new antimicrobials can be discovered and introduced into the market. The process of new drug development demands identification of novel targets in the pathogenic population. Conventional antibiotics have largely targeted bacterial cell wall synthesis, protein synthesis, or nucleic acid synthesis. However in recent years, quorum sensing (QS) machinery of the pathogenic bacteria has received considerable attention as potential target of novel anti-infective agents.