Research Article
N.L Prasanthi, S.S. Manikiran
Abstract
The objective of the present investigation was to found the effect of gums as binders namely acacia, tragacanth, guar gum, gum karaya and gum olibanum on the disintegration, dissolution rate and other qualities of Ziprasidone tablets. Based on dissolution rate (k1) and dissolution efficiency (DE60) values the order of performance of binders was gum karaya > acacia > gum olibanum > tragacanth > guar gum. Among all gum karaya and acacia gave significantly higher dissolution rate and DE60. Good correlation (r = 0.934) was observed between disintegration times and dissolution characteristics of various tablets.