KDR/VEGFR-2 Receptor Tyrosine Kinase Inhibitors and 3D QSAR (CoMFA and CoMSIA) Study

Arun Kumar Yasala, Tausif K

Abstract

ABSTRACT The review illustrates on the Vascular endothelial growth factor-A (VEGF-A) which shows pivotal roles in many angiogenic processes both in stable and pathological condition. Angiogenesis plays a key role in a number of pathology conditions with VEGFR-2 signals implicated in both tumour angiogenesis and diabetic retinopathy.