Original Articles
Charu Mendiratta, Vivek Kadam
Abstract
The aim of the present study was to prepare solid dispersion (SD) of Lansoprazole (LSP) to improve its saturation solubility and dissolution. SDs were prepared with a hydrophiphilic polymer PEG 4000 and a novel amphiphilic polymer Soluplus®. SD prepared using Soluplus® by solvent evaporation method gave highest saturation solubility. The prepared SD was further characterized by Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray Diffraction (XRD), Differential Scanning Colorimetry (DSC), Scanning Electron Microscopy (SEM) and in vitro drug dissolution. FTIR suggested formation of intermolecular hydrogen bonding between LSP and Soluplus®. DSC and XRD studies revealed partial amorphization when compared to pure LSP. The results of in vitro dissoultion in distilled water indicated a remarkable improvement in dissolution from the SD with 100% release in 20 mins when compared with the pure LSP (40% release in 120 mins).