Value Added Abstract
Radu Mihail Mirica, Mihai Ione
Matrix metalloproteinases (MMPs) are known ezymes involved in the modulation of extracellular matrix (ECM) and adipocyte and preadipocytes differentiation. Obesity implies a more or less rapid but generalized increase in adipose tissue (adipocyte and preadipocytes) and this proceses generate abnormal ECM metabolism. Aim: This study purpose was to determin if we can consider MMPs as a marker of effectiveness in bariatric surgery. Materials and methods: The experimental study used 20 obese wistar rats (10 in control group and 10 in Study group).The study group had gastric by-pass for obesity, and there were analised the pre and post operative MMP-2 and MMP-9. We compared the results in order to see if bariatric surgery modifies the MMPs status and if there is a correlation between the weight loss and the values of MMPs. Results: The MMP-2 and MMP-9 activities were detectable, but MMP-2 activity was signiï¬cantly higher than MMP-9. MMP-9 was strongly correlated with body weight parameters before surgery, as well as after significant body weight reduction as a result of bariatric surgery. There is a strong correlation between a greater weight loss and the values of MMP-2. Conclusions: MMP-2 and MMP-9 are the two most important proteins of ECM involved in adipose tissue remodeling after bariatric surgery. Although we believe that more in-depth studies are required, MMPs may be considered a marker of the effectiveness of bariatric surgery and weight loss.