Duminda Subasinghe1*, Ranjanie
Abstract
Menetrier’s disease is a rare premalignant hypertrophic gastropathy. It is characterized by upper gastrointestinal symptoms such as epigastric pain, discomfort, nausea, vomiting, peripheral oedema and hypertrophied gastric mucosal folds on endoscopy. An 80-year-old female presented with the complaints of severe epigastric pain, anorexia, vomiting, nausea and vomiting for 3 months. Upper gastrointestinal endoscopy and CT scan revealed thickening of gastric mucosa. Endoscopic biopsy showed gastric foveolar hyperplasia and glandular atrophy which are diagnostic for Menetrier’s disease. There was no evidence of Helicobacter pylori infection. Her laboratory investigations revealed hypoalbuminemia and anemia. She was symptomatically managed as she did not opt for any surgical intervention. Menetrier’s disease should be suspected in patients with upper gastrointestinal symptoms, hypoalbuminemia and hypertrophied gastric mucosa even without Helicobacter pylori infection. Preoperative diagnosis could not be confirmed unless adequate deep gastric biopsy is performed