Metformin hydrochloride: Density & Viscosity studies in mixed binary solvent in presence of additives

Mohd. Shafiq , Pathan Mohd Ari

Abstract

The densities and viscosities of metformin hydrochloride is determined in binary solvent ethanolwater containing salt NaCl, KCl, NiCl2, CuCl2 and a non electrolyte Glucose. The values are used to calculate excess viscosities, excess molar volume, excess Gibbs free energy of viscous flow and d12, T12 and H12 parameters. The result reveals that there are specific interaction between drug-metal ion, drug-water, drug-ethanol and water-ethanol.