Microwave-assisted an one–pot three component synthesis of 1,4-dihydropyrano [2,3-c] pyrazoles under solvent-free condition

Nana V.Shitole, Kiran F.Shelke

Abstract

A three component coupling process for synthesis of 6-amino-4-aryl-5- cyano-3-methyl–1–phenyl-2-pyrazolin-5-one from 3-methyl-1-phenyl–2- pyrazolin-5-one, aromatic aldehydes, malononitrile sodium hydrogen sulfate (NaHSO4) using as catalyst is described under microwave irradiation and solvent free condition. This method provides several advantages such as mild reaction condition, short reaction time, simple work up procedure and is environmentally friendly.