Might Estrogen Promote Lung Cancer Progression?

Vianey Rodriguez Lara

Abstract

In order to understand the differences between sexes in lung cancer presentation and due to the observation that young women have worse prognosis, we studied the participation of estrogens in lung carcinogenesis. We found that estradiol increases the expression of CXCR4 and promotes the activation of the CXCL12/CXCR4 axis, an important chemokine pathway involved in lung carcinogenesis and tumor progression.