Review Article
Sandip K Mishra, Debomita S
Abstract
Age is one of the most important risk factors for human malignancies, including breast cancer. In relation to increase in breast cancer incidence, aging can significantly alter breast cancer biology as defined by validated prognostic and predictive biomarkers. Despite awareness that breast cancer and other cancers are primarily agerelated diseases, molecular and cellular hypothesis explaining the cancer-aging relationship have only recently emerged and remain clinically unproven. Here we review the series of key observations that has led to complex but growing convergence between our understanding of the biology of aging and the mechanisms underlying breast cancer occurrence.